Hydrochloric Acid → HCID 23105929, compound
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:12]C=O)([CH3:11])[CH3:10])=[CH:4][C:3]=1[C:15]([F:18])([F:17])[F:16].Cl.C(=O)([O-])[O-].[K+].[K+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:4][C:3]=1[C:15]([F:16])([F:17])[F:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
3.30 g (12.5 mmol) N-[2-(4-fluoro-3-trifluoromethyl-phenyl)-1,1-dimethyl-ethyl]-formamide are combined with 25 mL water and 25 mL conc. hydrochloric acid and refluxed for 2 hours. The reaction mixture is diluted with water, made alkaline with potassium carbonate solution and extracted with dichloromethane. The combined organic phases are dried with sodium sulphate and freed from solvent. Brown oil.