L-(+)-Cysteine → HCID 14881540, compound

HRID 129727

Reaction equation

HRID 129727 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=O.[NH2:15][C@H:16]([C:19]([OH:21])=[O:20])[CH2:17][SH:18]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:15][CH:16]([C:19]([OH:21])=[O:20])[CH2:17][S:18]1

Participants

4

Reactant 2

HCID 5862L-(+)-CysteineHCID 88065Bis(2-pyridyl) ketone

Product 1

HCID 14881540HCID 14881540, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.68 g of di-2-pyridyl ketone, 2.42 g of L-cysteine, 25 ml of ethanol was refluxed for 3.5 hours. After allowing the mixture to cool, the insoluble matter was filtered off, and the filtrate was concentrated to dryness under reduced pressure. The residue was washed in sequence with ethyl acetate and ether to give 0.63 g of 2,2-di(2-pyridyl)-thiazolidine-4-carboxylic acid.

Workup

  1. temperaturewas refluxed for 3.5 hours
  2. temperatureto cool
  3. filtrationthe insoluble matter was filtered off
  4. concentrationthe filtrate was concentrated to dryness under reduced pressure
  5. washThe residue was washed in sequence with ethyl acetate and ether

Sources & evidence

ORD record
ord-fbee9d5e5b41400f9f3691bf051546d4
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Linked notes

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