Hydrogen Peroxide → 3-(4-Formyl-phenoxymethyl)-benzamide

HRID 130479

Reaction equation

HRID 130479 reaction equation
[CH:1]([C:3]1[CH:18]=[CH:17][C:6]([O:7][CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])=[CH:5][CH:4]=1)=[O:2].C(=O)([O-])[O-:20].[K+].[K+].OO>CS(C)=O>[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]([NH2:13])=[O:20])=[CH:17][CH:18]=1)=[O:2]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 176086763-[(4-Formylphenoxy)methyl]benzonitrile

Product 1

HCID 471728313-(4-Formyl-phenoxymethyl)-benzamide

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 3-(4-Formyl-phenoxymethyl)benzonitrile (1 equiv), in DMSO was added potassium carbonate (0.5 equiv), and hydrogen peroxide (4 equiv). The reaction mixture stirred at room temperature for 2 hours. The reaction was monitored by TLC. It was poured on water and extracted with ethyl acetate (×3). The organic phase was dried over magnesium sulphate, filtered and concentrated under vacuum to yield a white solid.

Workup

  1. additionIt was poured on water
  2. extractionextracted with ethyl acetate (×3)
  3. dry with materialThe organic phase was dried over magnesium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum
  6. customto yield a white solid

Sources & evidence

ORD record
ord-b846b8b452874160bf4fee4b5eca3a8f
Source dataset
uspto-grants-2008_06
Patent number
US07381750B2

Linked notes

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