Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>F[B-](F)(F)F.c1c[n+](C23CC4CC(CC(C4)C2)C3)cn1C12CC3CC(CC(C3)C1)C2.C[Si](C)(C)[N-][Si](C)(C)C.[Na+].COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC>Cn1c(=O)c2c(ncn2C)n(C)c1=O.FC(F)(F)c1ccc(N2CCOCC2)cc1.FC(F)(F)c1cccc(N2CCOCC2)c1Participants
8
Reactant 2
Product 3
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 60 °C
Workup
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Sources & evidence
- ORD record
- ord-9a1afcc4876d4c83aa4a6c8a7d85ede4
- Source dataset
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Original link
- View source
Reaction notes
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