Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>COCCOCCOC.C[O]1CC[O](C)->[Ni]<-1([Cl])[Cl].C[Si](C)(C)[N-][Si](C)(C)C.F[B-](F)(F)F.[Na+].c1c[n+](C23CC4CC(CC(C4)C2)C3)cn1C12CC3CC(CC(C3)C1)C2>FC(F)(F)c1ccc(N2CCOCC2)cc1Participants
9
Reactant 2
Product 3
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 60 °C
Workup
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Sources & evidence
- ORD record
- ord-0e6a75b5e88d49ea8fa79c33961fed58
- Source dataset
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Original link
- View source
Reaction notes
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