Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

Reaction equation

C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].COCCOCCOC.CS(C)=O.Clc1ccc(-n2cc[n+](-c3ccc(Cl)cc3)c2)cc1.[Cl-].[Cl][Cu].[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

ORD record: ord-d578ca903c4b4880bbfd8ebb33405d20
Source dataset: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
Original link: View source

Loading…

customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

ORD record: ord-d578ca903c4b4880bbfd8ebb33405d20
Source dataset: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
Original link: View source

Loading…