3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
Reaction equation
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC#[N]->[Cu+](<-[N]#CC)(<-[N]#CC)<-[N]#CC.CN1CCCN2CCCN=C12.COc1ccc(P(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1.CS(C)=O.F[B-](F)(F)F>c1ccc(C2CCN(c3cccnc3)CC2)cc1Participants
9
Reactant 2
Product 3
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 60 °C
Workup
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Sources & evidence
- ORD record
- ord-1e9e526e8ecd42149e4e83b2ca25de12
- Source dataset
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Original link
- View source
Reaction notes
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