Thionyl Chloride → 3-Benzyloxy-1-(2,2-dimethoxyethyl)-5-hydroxymethyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide

5-Benzyloxy-6-(3-chlorobenzylcarbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (517 mg) obtained in Example 161, Step 4 and triethylamine (0.43 ml) were added to tetrahydrofuran (7 ml), and thionyl chloride (0.098 ml) was subsequently added at 0° C. The mixture was stirred at room temperature for 3 min and the reaction mixture was cooled to −78° C. 1M Lithium aluminum hydride/tetrahydrofuran solution (1.55 ml) was added dropwise. After stirring at the same temperature for 3 min, 5% aqueous potassium hydrogen sulfate solution was added, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried, concentrated and purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=20:1) to give 3-benzyloxy-1-(2,2-dimethoxyethyl)-5-hydroxymethyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide (240 mg).

1. additionwas subsequently added at 0° C
2. temperaturethe reaction mixture was cooled to −78° C
3. stirringAfter stirring at the same temperature for 3 min
4. extractionthe mixture was extracted with ethyl acetate
5. dry with materialThe ethyl acetate layer was dried
6. concentrationconcentrated
7. custompurified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=20:1)

ORD record

ord-ab3e690a2a294fa7b541457ec8d9b959

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07211572B2