p-Fluorophenethylamine → HCID 21098561, compound

HRID 1351256Notes

Reaction equation

HRID 1351256 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH:11]([N:14](CC)C(C)C)(C)[CH3:12].BrCC#N>C(#N)C.C(OCC)(=O)C>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH2:12][C:11]#[N:14])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 4653p-FluorophenethylamineHCID 11534BromoacetonitrileHCID 81531Diisopropylethylamine

Product 1

HCID 21098561HCID 21098561, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-fluorophenethylamine (1.4 g) in acetonitrile (20 mL) was added dropwise N,N-diisopropylethylamine (2.6 mL) and bromoacetonitrile (0.84 mL). After stirring at room temperature for 50 minutes, the solution was diluted with ethyl acetate, the solution was washed with water, then with saturated sodium chloride water. After drying with anhydrous sodium sulfate, the solvent was removed by evaporation to provide the title compound (2.12 g) as a yellow oily substance.

Workup

  1. washthe solution was washed with water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-4a0da7085a9d4a9db625dd90774ae72a
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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