Pyridine → 2-Chloro-5-methylsulfonyloxymethyl-thiazole

Reaction equation

[CH3:1][S:2](=[O:3])(=[O:4])[O:5][S:6](=[O:7])(=[O:8])[CH3:9].[Cl:10][c:11]1[s:12][c:13]([CH2:16][OH:17])[cH:14][n:15]1.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[cH:18]1[cH:19][cH:20][n:21][cH:22][cH:23]1>>[O:5]([S:6](=[O:7])(=[O:8])[CH3:9])[CH2:16][c:13]1[s:12][c:11]([Cl:10])[n:15][cH:14]1

Participants

Reactant 4

HCID 1049Pyridine

HCID 8028Tetrahydrofuran

HCID 81560Methanesulfonic anhydride

HCID 2763180(2-Chloro-1,3-thiazol-5-yl)methanol

Product 1

HCID 211830762-Chloro-5-methylsulfonyloxymethyl-thiazole

Sources & evidence

ORD record: ord-080ea2babbab4f7f96c8170832883fdb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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