Hydrochloric Acid → Tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Reaction equation

[CH2:20]1[O:21][CH2:22][CH2:23][CH2:24]1.[ClH:19].[OH2:18].[OH:1][CH:2]1[CH2:3][CH:4]([C:14](=[O:15])[O:16][CH3:17])[N:5]([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:6]1>>[OH:1][CH:2]1[CH2:3][CH:4]([CH2:14][OH:15])[N:5]([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:6]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 51482991-Tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Product 1

HCID 4204845Tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record: ord-f9542effe39e4006a27cd6e685c5b354
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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