7-Fluoro-1H-indole → 3-(1-Ethyl-5-fluoro-indan-1-yl)-7-fluoro-1H-indole

HRID 13705

Reaction equation

HRID 13705 reaction equation
[CH2:1]([C:3]1(O)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[F:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[NH:22][CH:21]=[CH:20]2>>[CH2:1]([C:3]1([C:20]2[C:19]3[C:23](=[C:15]([F:14])[CH:16]=[CH:17][CH:18]=3)[NH:22][CH:21]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 27745047-Fluoro-1H-indoleHCID 593404281-Ethyl-5-fluoroindan-1-ol

Product 1

HCID 115656213-(1-Ethyl-5-fluoro-indan-1-yl)-7-fluoro-1H-indole

Procedure

Utilizing 1-ethyl-5-fluoro-indan-1-ol and 7-fluoroindole, the title compound is prepared as in example 1. 217 mg (92%). NMR (400 MHz, CDCl3): δ 0.85 (t, 3H), 2.12 (m, 1H), 2.21 (m, 1H), 2.31 (m, 1H), 2.58 (m, 1H), 2.97 (m, 2H), 6.83 (m, 4H), 6.98 (m, 3H), 8.06 (s, 1H, NH).

Sources & evidence

ORD record
ord-b888e303295143afa63cc5b1e99b8fb2
Source dataset
uspto-grants-2010_06
Patent number
US07728150B2

Linked notes

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