Chloride → 4-Chloro-6-(2,6-difluorobenzyl)pyrimidine

HRID 137198

Reaction equation

HRID 137198 reaction equation
[Br:1][CH:2]([Br:3])[CH3:4].[CH3:6][SiH:7]([CH3:8])[CH3:9].[Cl-:5].[Cl:20][c:21]1[n:22][cH:23][n:24][c:25]([Cl:27])[cH:26]1.[F:10][c:11]1[c:12]([CH2:13][Br:14])[c:15]([F:19])[cH:16][cH:17][cH:18]1.[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1.[OH2:34].[Zn:33]>>[F:10][c:11]1[c:12]([CH2:13][c:25]2[n:24][cH:23][n:22][c:21]([Cl:20])[cH:26]2)[c:15]([F:19])[cH:16][cH:17][cH:18]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 962WaterHCID 8028TetrahydrofuranHCID 112011,1-DibromoethaneHCID 23994ZincHCID 70435TrimethylsilaneHCID 709434,6-DichloropyrimidineHCID 5814352-(Bromomethyl)-1,3-difluorobenzene

Product 1

HCID 225997014-Chloro-6-(2,6-difluorobenzyl)pyrimidine

Sources & evidence

ORD record
ord-2a6e8e4f65934776a9ca6880551126f1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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