2-Amino-5-bromopyridine → N'-(5-Bromopyridin-2-yl)-N,N-dimethylformimidamide
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]=[CH:11][N:12]([CH3:14])[CH3:13])=[N:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
To a stirred solution of 5-bromo-2-aminopyridine (3.0 g, 17.3 mmol) in N,N-dimethylformamide (6 mL) was added N,N-dimethylformamide dimethyl acetal (5.37 g, 45.0 mmol). The reaction mixture was heated to 130° C. overnight. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the desired product as a brown oil. LC/MS 227.8 (M+1)
Workup
- temperatureAfter cooling to room temperature
- customthe volatiles were removed under reduced pressure
Sources & evidence
- ORD record
- ord-a33dca15574b492b92aac01dada5ac40
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07157490B2
Reaction notes
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