Potassium Carbonate → 4-[((2S)-2-Amino-3-{7-[2-(1H-pyrrol-1-yl)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)oxy]benzonitrile

A mixture of tert-butyl (1S)-2-(4-cyanophenoxy)-1-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-ylmethyl)ethylcarbamate (Preparation J; 100.62 mg, 0.25 mmol), 1-(2-bromoethyl)pyrrole (52.21 mg, 0.30 mmol) and TEA (37.9 mg, 0.375 mmol) in DMF (2.5 mL) was stirred at rt for 2 days and then at 50° C. for 1 day. The solvent was evaporated and the resulting residue dissolved in ethyl acetate (0.5 mL). Ethyl acetate saturated with gaseous hydrochloric acid (2 mL) was added, and the reaction mixture stirred for 1.5 h at rt. The solvent was evaporated and the resulting residue dissolved in a mixture of MeCN (2.5 mL) and H2O (0.13 mL). Potassium carbonate (100 mg, 0.72 mmol) was added, and the mixture stirred overnight at rt. The mixture was filtered and the filtrate concentrated in vacuo. The resulting crude product was dissolved in DCM (2 mL), which solution was added to a ion-exchange solid-phase extraction plug (CBA, 2 g). After 80 min, the product was eluted with DCM:MeCN (4×2 mL of 4:1), followed by DCM:MeOH:TEA (8:1:1), to give 89.7 mg (90.7%) of the title compound.

1. waitat 50° C. for 1 day
2. customThe solvent was evaporated
3. dissolutionthe resulting residue dissolved in ethyl acetate (0.5 mL)
4. additionEthyl acetate saturated with gaseous hydrochloric acid (2 mL) was added
5. stirringthe reaction mixture stirred for 1.5 h at rt
6. customThe solvent was evaporated
7. dissolutionthe resulting residue dissolved in a mixture of MeCN (2.5 mL) and H2O (0.13 mL)
8. stirringthe mixture stirred overnight at rt
9. filtrationThe mixture was filtered
10. concentrationthe filtrate concentrated in vacuo
11. dissolutionThe resulting crude product was dissolved in DCM (2 mL)
12. additionwhich solution was added to a ion-exchange solid-phase extraction plug (CBA, 2 g)
13. waitAfter 80 min
14. washthe product was eluted with DCM

ORD record

ord-1e651fd6de3f4ef7a6c915f051ab9dc6

Source dataset

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07164017B2