Dimethyl malonate → HCID 16638931, compound
Reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH2:14][CH2:15]I.C(=O)([O-])[O-].[K+].[K+].[CH3:23][O:24][C:25](=[O:31])[CH2:26][C:27]([O:29][CH3:30])=[O:28]>CN(C=O)C>[CH3:23][O:24][C:25](=[O:31])[CH:26]([CH2:15][CH2:14][C:3]1[CH:4]=[C:5]([O:10][CH:11]([CH3:13])[CH3:12])[C:6]([O:8][CH3:9])=[CH:7][C:2]=1[Br:1])[C:27]([O:29][CH3:30])=[O:28]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Bromo-2-(2-iodoethyl)-4-(1-methylethoxy)-5-methoxybenzene (18.0 g, 45.1 mmol), potassium carbonate (32.0 g, 321 mmol, anhydrous, freshly ground) and malonic acid dimethyl ester (50.0 g, 378 mmol) are stirred in absolute DMF (200 ml) for 12 hours at 80° C.