Dimethyl malonate → HCID 16637924, compound
Reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1.[CH3:13][O:14][C:15](=[O:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:13][O:14][C:15](=[O:21])[CH:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1)[C:17]([O:19][CH3:20])=[O:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1-(Chloromethyl)-4-(1-methylethoxy)benzene (20.5 g, 111 mmol), malonic acid dimethyl ester (102.5 g, 776 mmol) and potassium carbonate (46.5 g, 332 mmol, anhydrous, freshly ground) are stirred in absolute DMF (250 ml) for 24 hours at 70° C.
Sources & evidence
- ORD record
- ord-348b4781162e47d9b7cc0228d2c279e0
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07166588B2
Reaction notes
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