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Hydrochloric Acid → HCID 70266804, compound

HRID 1378451
Notes
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Reaction equation

HRID 1378451 reaction equation
[CH3:1][O:2][C:3](=[O:29])[C@H:4]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[NH:5][C:6]([C:8]1([NH:13]C(OC(C)(C)C)=O)[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7].[ClH:30]>ClCCl.C(OCC)(=O)C>[ClH:30].[CH3:1][O:2][C:3](=[O:29])[C@H:4]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([OH:28])=[CH:26][CH:27]=1)[NH:5][C:6]([C:8]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10549319N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine methyl ester

Product 1

HCID 70266804HCID 70266804, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]-carbonyl]-L-tyrosine methyl ester (3.50 g, 8.6 mmol) in dichloromethane (60 mL) and ethyl acetate (10 mL) is bubbled dry HCl gas for 15 minutes. The solvent is then removed under reduced pressure to give, as a foam, [[1-amino(1-cyclopentyl)]carbonyl]-L-tyrosine methyl ester hydrochloride.

Workup

  1. customThe solvent is then removed under reduced pressure

Sources & evidence

ORD record
ord-455234fd114341c4a9d58850621a802a
Source dataset
uspto-grants-1997_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05668158

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes