Sodium Bicarbonate → HCID 178515951, compound
Reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][NH:12][N:11]=1.C(=O)(O)[O-].[Na+]>Br>[NH:12]1[CH:13]=[CH:14][C:10]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[OH:2])=[N:11]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The product of step (b) (4.6 g) was dissolved in 48% aqueous HBr (100 ml) and refluxed for 8 hours. The mixture was poured onto water (750 ml), neutralised with solid sodium bicarbonate, extracted with ethyl acetate, washed with brine and evaporated to give the title compound as a white crystalline solid, 0.49 g, mp 163°-4° (from ethyl acetate/cyclohexane).
Workup
- temperaturerefluxed for 8 hours
- additionThe mixture was poured onto water (750 ml)
- extractionextracted with ethyl acetate
- washwashed with brine
- customevaporated
Sources & evidence
- ORD record
- ord-8a642681a8dc47b3a587b47fa7d6538b
- Source dataset
- uspto-grants-1989_02
- Patent number
- US04803216
Reaction notes
Loading…