Hydrochloric Acid → HCID 14838488, compound

Reaction equation

C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=1.C(=O)(O)[O-].[Na+].[ClH:21]>ClCCl>[ClH:21].[CH3:15][N:12]1[CH:13]=[CH:14][C:10]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[OH:2])=[N:11]1

Participants

Procedure

The pyrazole from step (a) (1.7 g) was dissolved in dichloromethane (30 ml) under an atmosphere of nitrogen. Brown tribromide (8 ml) in dichloromethane was added dropwise and the mixture stirred at room temperature for 24 hours. After addition of dilute sodium bicarbonate, the organic phase was removed, dried and evaporated to give a pale oil, which was converted to the hydrochloride salt of the title compound, by trituration with ethereal HCl, to give an off-white solid, 0.75 g, mp 162°-164°.