Methane → 5-Methyl-2-sulfamoyl-furan-3-carboxylic acid

HRID 1388188

Reaction equation

HRID 1388188 reaction equation
C([NH:5][S:6]([C:9]1[O:10][C:11]([CH3:17])=[CH:12][C:13]=1[C:14]([OH:16])=[O:15])(=[O:8])=[O:7])(C)(C)C.C>C(OCC)(=O)C>[CH3:17][C:11]1[O:10][C:9]([S:6](=[O:8])(=[O:7])[NH2:5])=[C:13]([C:14]([OH:16])=[O:15])[CH:12]=1

Participants

4

Reactant 2

HCID 297MethaneHCID 867392172-(N-tert. butyl)sulfamoyl-5-methyl-furan-3-carboxylic acid

Product 1

HCID 204718985-Methyl-2-sulfamoyl-furan-3-carboxylic acidYield 92.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Boiling stones and 42 gm (0.12 mol) of 2-(N-tert. butyl)sulfamoyl-5-methyl-furan-3-carboxylic acid were heated in a round bottom flask for 2 hours at 150° C. The cooled reaction mixture was taken up in 1 liter of ethyl acetate. After refluxing the solution was treated with activated charcoal, filtered and evaporated. 22.8 gm (69% of theory) of crystalline 5-methyl-2-sulfamoyl-furan-3-carboxylic acid were obtained.

Workup

  1. customThe cooled reaction mixture
  2. temperatureAfter refluxing the solution
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-bb2db5612cca4a71922e3fe9e8157c13
Source dataset
uspto-grants-1984_02
Patent number
US04430355

Linked notes

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