Tetrahydrofuran → 2,4-Dichloro-6-[2-(4-chlorophenyl)ethyl]pyrimidine

HRID 138909

Reaction equation

HRID 138909 reaction equation
[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl:18][c:19]1[cH:20][cH:21][c:22]([CH2:23][Br:24])[cH:25][cH:26]1.[Cl:9][c:10]1[n:11][c:12]([CH3:17])[cH:13][c:14]([Cl:16])[n:15]1.[Li+:8].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[Cl:9][c:10]1[n:11][c:12]([CH2:17][CH2:23][c:22]2[cH:21][cH:20][c:19]([Cl:18])[cH:26][cH:25]2)[cH:13][c:14]([Cl:16])[n:15]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 794712,4-Dichloro-6-methylpyrimidineHCID 5062348Diisopropylamide

Product 1

HCID 221700472,4-Dichloro-6-[2-(4-chlorophenyl)ethyl]pyrimidine

Sources & evidence

ORD record
ord-2d23c9a60f0b41c096b8caa4a371c04a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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