Acetone → phenyl-Alanine
Reaction equation
OC([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(C)C#N.[CH3:12][C:13]([CH3:15])=O.[OH-:16].[Na+].[NH4+:18].[OH-:19]>[C-]#N.[K+]>[C:6]1([NH:18][C@H:13]([C:15]([OH:19])=[O:16])[CH3:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Following the same mode of operation as in the above example, starting with 0.14 g (approx. 10-3 mol) of α-hydroxyphenyl propionitrile in 2 ml of 0.1 M solution in KCN and 0.2 M in NH4OH 10 N, and after adding 0.06 g of acetone and 0.11 ml of NaOH 10 N after neutralisation, quantitative analysis by an analyst of α-amino acids gave a yield of 85% of phenyl alanine.
Sources & evidence
- ORD record
- ord-f0497aef095141fb94ff8352effe82ef
- Source dataset
- uspto-grants-1981_01
- Patent number
- US04243814
Reaction notes
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