Tetrahydrofuran → 5-Fluoro-2-(3-pyrrolidin-1-ylmethyl-benzo[d]isoxazol-6-yloxy)-benzylamine

Reaction equation

[Al+3:27].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[F:1][c:2]1[cH:3][cH:4][c:5]([O:10][c:11]2[cH:12][c:13]3[c:14]([c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[n:16][o:17]3)[cH:24][cH:25]2)[c:6]([C:7]#[N:8])[cH:9]1.[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28]>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:10][c:11]2[cH:12][c:13]3[c:14]([c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[n:16][o:17]3)[cH:24][cH:25]2)[c:6]([CH2:7][NH2:8])[cH:9]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 674101705-Fluoro-2-(3-pyrrolidin-1-ylmethyl-benzo[d]isoxazol-6-yloxy)-benzonitrile

Product 1

HCID 674094985-Fluoro-2-(3-pyrrolidin-1-ylmethyl-benzo[d]isoxazol-6-yloxy)-benzylamine

Sources & evidence

ORD record: ord-48bf2d8ed604419ab5f7bad061810388
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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