2-Bromopropane → HCID 12505026, compound

HRID 1395107Notes

Reaction equation

HRID 1395107 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[SH:10])([O-:3])=[O:2].Br[CH:12]([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH:12]([S:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 21002o-Nitrobenzenethiol

Product 1

HCID 12505026HCID 12505026, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Nitrothiophenol, 2-bromopropane, potassium carbonate and acetone were refluxed for several hours. The solvent then was removed by rotary evaporation. The crude product was partitioned between methylene chloride and a 10% sodium carbonate solution. The organic phase was distilled to yield 2-isopropylmercaptonitrobenzene.

Workup

  1. customThe solvent then was removed by rotary evaporation
  2. customThe crude product was partitioned between methylene chloride
  3. distillationThe organic phase was distilled

Sources & evidence

ORD record
ord-d6d6d8edf9324ff78a7de0fc55818bb5
Source dataset
uspto-grants-1980_05
Patent number
US04202821

Reaction notes

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