Lithium Hydroxide → HCID 67467360, compound
Reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([F:14])[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]=12)=[O:4].[OH-].[Li+]>O1CCCC1>[F:14][C:7]1[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]2=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 6-fluoro-benzothiazole-4-carboxylic acid methyl ester (1.97 g, 9.33 mmol) in tetrahydrofuran (30 mL) was added aqueous lithium hydroxide solution (2M, 14.0 mL, 28 mmol, 3 eq.) and then stirred, at room temperature, for 4 hr. The reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL) and stirred for 15 min. The resulting suspension was filtered and the solid produced was washed with water and air dried to give the title compound as a grey solid (1.51 g, 82%).
Workup
- customThe reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL)
- stirringstirred for 15 min
- filtrationThe resulting suspension was filtered
- customthe solid produced
- washwas washed with water and air
- customdried
Sources & evidence
- ORD record
- ord-4bf6b7af6c3740719a1f51777b9d8357
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08916593B2
Reaction notes
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