Water → N-{2,4-difluoro-3-[hydroxy-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-phenyl}-3-methoxy-benzenesulfonamide

HRID 140877

Reaction equation

HRID 140877 reaction equation
[CH:21]([N-:22][CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[CH:29]([CH3:30])([CH3:31])[Si:32]([n:33]1[cH:34][c:35]([CH:42]=[O:43])[c:36]2[c:37]1[n:38][cH:39][cH:40][cH:41]2)([CH:44]([CH3:45])[CH3:46])[CH:47]([CH3:48])[CH3:49].[F:1][c:2]1[c:3]([NH:9][S:10](=[O:11])(=[O:12])[c:13]2[cH:14][c:15]([O:19][CH3:20])[cH:16][cH:17][cH:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Li+:28].[O:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1.[OH2:50]>>[F:1][c:2]1[c:3]([NH:9][S:10](=[O:11])(=[O:12])[c:13]2[cH:14][c:15]([O:19][CH3:20])[cH:16][cH:17][cH:18]2)[cH:4][cH:5][c:6]([F:8])[c:7]1[CH:42]([c:35]1[cH:34][n:33]([Si:32]([CH:29]([CH3:30])[CH3:31])([CH:44]([CH3:45])[CH3:46])[CH:47]([CH3:48])[CH3:49])[c:37]2[c:36]1[cH:41][cH:40][cH:39][n:38]2)[OH:43]

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 497589651H-Pyrrolo[2,3-B]pyridine-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-HCID 58086624N-(2,4-difluorophenyl)-3-methoxybenzenesulfonamide

Product 1

HCID 58182210N-{2,4-difluoro-3-[hydroxy-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-phenyl}-3-methoxy-benzenesulfonamide

Sources & evidence

ORD record
ord-3109d925f6bd404192d8e475df3ae188
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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