Piperidin-4-ol → HCID 67608386, compound
Reaction equation
Br[C:2]1[CH:7]=[N:6][C:5]([CH2:8][CH3:9])=[CH:4][N:3]=1.[OH:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C(O)(C)C>[CH2:8]([C:5]1[N:6]=[CH:7][C:2]([N:14]2[CH2:15][CH2:16][CH:11]([OH:10])[CH2:12][CH2:13]2)=[N:3][CH:4]=1)[CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
A mixture of 2-bromo-5-ethyl-pyrazine (1.66 g) and 4-hydroxy-piperidine (2.24 g) in isopropanol (15 mL) is heated in an autoclave to 150° C. over night. The solvent is evaporated in vacuo and the residue is mixed with water and dichloromethane. The aqueous phase is extracted with dichloromethane and the combined organic phases are washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound. LC (method 7): tR=0.66 min; Mass spectrum (ESI+): m/z=208 [M+H]+.