Hydrochloric Acid → 1-Ethyl-4-methylpiperazine
Reaction equation
Cl.C(=O)([O-])[O-].[Na+].[Na+].Cl.Cl.[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18]Cl)[CH2:13][CH2:12]1>C(O)(C)C>[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH3:18])[CH2:13][CH2:12]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.75 g of raubasinic acid hydrochloride in 100 ml of anhydrous isopropanol in the presence of 3.20 g of anhydrous sodium carbonate is heated under reflux with agitation and in nitrogen atmosphere with 2.35 g of 1-methyl-4β chlorethylpiperazine dihydrochloride. After 4 hours the mixture is treated as in Example 1. One obtains 3.2 g of 1-methyl-4β ethylpiperazine raubasinate hydrochloride.
Workup
- additionAfter 4 hours the mixture is treated as in Example 1
Sources & evidence
- ORD record
- ord-5e4d376b80854210b71fe7a528f84898
- Source dataset
- uspto-grants-1977_01
- Patent number
- US04002633
Reaction notes
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