Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

HRID 1415478

Reaction equation

HRID 1415478 reaction equation
Cl.[CH3:2][O:3][NH2:4].C(N(CC)CC)C.[CH:12]1([N:22]=[C:23]=[S:24])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[CH3:2][O:3][NH:4][C:23]([NH:22][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1)=[S:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 213934961-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.

Workup

  1. additionis added dropwise
  2. filtrationfiltered
  3. washThe filtrate is washed with water
  4. dry with materialdried (sodium sulfate)
  5. customthe solvent evaporated at reduced pressure

Sources & evidence

ORD record
ord-fe2c7237231b464bbce50bf2fe5a121f
Source dataset
uspto-grants-1977_01
Patent number
US04005140

Linked notes

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