Methylamine → HCID 21482809, compound

HRID 1415545

Reaction equation

HRID 1415545 reaction equation
[H][H].[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][C:7](=O)[CH2:6]1)[CH3:4].[CH3:12][NH2:13]>[Pt](=O)=O.CO>[CH2:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([NH:13][CH3:12])[CH2:6]1)[CH3:4]

Participants

6

Reactant 3

HCID 6329MethylamineHCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21482809HCID 21482809, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A suspension of 0.25 g. of platinum dioxide in 20 ml. of methanol was shaken under 30 p.s.i. of hydrogen for one hour. To this activated catalyst was added a solution of 7.9 g. (48 mmoles) of 1-ethyl-3-piperidone and 3.1 g. (100 mmoles) of methylamine in 40 ml. of methnol. This mixture was shaken under about 50 p.s.i. of hydrogen for 1.5 hours, then filtered. The solvent was distilled off the filtrate at atmospheric pressure. The residue was then distilled at reduced pressure to give 1-ethyl-3-methylaminopiperidine, b.p. 88°-90.5° C. at 28 mm.

Workup

  1. additionA suspension of 0.25 g
  2. additionTo this activated catalyst was added a solution of 7.9 g
  3. filtrationfiltered
  4. distillationThe solvent was distilled off the filtrate at atmospheric pressure
  5. distillationThe residue was then distilled at reduced pressure

Sources & evidence

ORD record
ord-abf4998b4ba34c66bc8fbc364e15c119
Source dataset
uspto-grants-1977_01
Patent number
US04005208

Linked notes

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