Methane → 3-Aminohexanoic acid

HRID 1421334Notes

Reaction equation

HRID 1421334 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].C.[OH-].[NH4+:11]>>[NH2:11][CH:3]([CH2:4][CH2:5][CH3:6])[CH2:2][C:1]([OH:8])=[O:7]

Participants

4

Reactant 3

HCID 297MethaneHCID 8892Hexanoic AcidHCID 14923Ammonium Hydroxide

Product 1

HCID 52756453-Aminohexanoic acid

Conditions

Temperature
150 °C

Procedure

A mixture of 2 hexanoic acid (7.0 g, 0.06 mole) and concentrated aqueous ammonium hydroxide (70 ml) is heated for 24 hours in an autoclave at 150° C. The cooled mixture is treated with carbon black and filtered. After evaporation of the solvent, the crude product is recrystallized from ethanol to give the title compound m.p. 203° C. (Compound 1.21, Table 1).

Workup

  1. filtrationfiltered
  2. customAfter evaporation of the solvent
  3. customthe crude product is recrystallized from ethanol

Sources & evidence

ORD record
ord-3e066ec21d4e4a9d8864e13b0a802682
Source dataset
uspto-grants-2000_06
Patent number
US06075051

Reaction notes

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