Hydrochloric Acid → 3-Chloro-1-(naphthalen-2-yl)propan-1-one
Reaction equation
ClCC[CH2:4][CH2:5][C:6](Cl)=[O:7].[CH:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1.[Cl-:19].[Al+3].[Cl-].[Cl-].Cl>[N+](C1C=CC=CC=1)([O-])=O>[Cl:19][CH2:4][CH2:5][C:6]([C:15]1[CH:16]=[CH:17][C:18]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=1)=[O:7]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
2-chloroethylpropionyl chloride (2.78 g), naphthalene (2.56 g), and aluminium chloride (3.2 g) were reacted in nitrobenzene (9 mL) at 0° C., followed by treatment with hydrochloric acid to obtain the title compound (1.5 g).
Sources & evidence
- ORD record
- ord-6f584296aa404fb38203d9e4b19fff00
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08937091B2
Reaction notes
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