Citric Acid → HCID 178493585, compound
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.C1N2CCN(CC2)C1.C(=O)([O-])[O-:21].[K+].[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:11][O:10][C:4]1[N:3]=[C:2]([OH:21])[CH:7]=[C:6]([O:8][CH3:9])[N:5]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of 4-chloro-2,6-dimethoxy-pyrimidine (4.9 g, 28 mmol), DABCO (6.4 g, 57 mmol) and potassium carbonate (13.8 g, 100 mmol) was refluxed in water (150 ml) for one hour. The mixture was cooled acidified with 5% citric acid and extracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH. The combined organic phases were dried and evaporated which gave the title compound (1.5 g, 34%), (M+H)+1 157.
Workup
- temperatureThe mixture was cooled
- extractionextracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH
- customThe combined organic phases were dried
- customevaporated which
Sources & evidence
- ORD record
- ord-d6bed3b2bfe94e3ca2d89ac0f0149c68
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08937080B2
Reaction notes
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