Hydrochloric Acid → HCID 91658617, compound

HRID 1436376

Reaction equation

HRID 1436376 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]([C:7]1([NH:10]C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6])[CH3:3]>C(OCC)(=O)C>[Cl-:1].[CH2:2]([O:4][C:5]([C:7]1([NH3+:10])[CH2:9][CH2:8]1)=[O:6])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10242916Ethyl 1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

Product 1

HCID 91658617HCID 91658617, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A saturated solution of HCl in ethyl acetate (20 mL) was added under nitrogen to a solution of 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropane carboxylic acid ethyl ester (10.07 g, 43.9 mmol), prepared in the previous step, in 20 mL of ethyl acetate at room temperature. After the addition, the reaction was stirred at room temperature for 1 h. The solid present was collected by filtration, rinsed with ethyl acetate and dried under reduced pressure to give 1-ethoxycarbonyl-cyclopropyl-ammonium chloride as a white solid.

Workup

  1. additionAfter the addition
  2. filtrationThe solid present was collected by filtration
  3. washrinsed with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-147f78c6847047b6a58b7ae09f3f9b92
Source dataset
uspto-grants-2009_11
Patent number
US07618990B2

Linked notes

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