5-Nitrophthalazin-1(2H)-one → 5-amino-1(2H)-phthalazinone
Reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[N:7][NH:8][C:9]2=[O:14])([O-])=O.[H][H]>[Pd].C(OCC)(=O)C.C(N(CC)CC)C>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[N:7][NH:8][C:9]2=[O:14]Participants
6
Procedure
980 mg of 5-nitro-phthalazin-1-one (Example 66) and 100 mg of palladium on activated carbon are suspended in 50 ml of ethyl acetate and 1 ml of triethylamine, and it is hydrogenated with hydrogen under normal pressure. It is filtered through diatomaceous earth, and the solvent is removed in a vacuum. 830 g of 5-amino-phthalazin-1-one as a solid is obtained as a crude product.
Workup
- filtrationIt is filtered through diatomaceous earth
- customthe solvent is removed in a vacuum
Sources & evidence
- ORD record
- ord-c5cdcc1f9f1a46028191b565dee87293
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07659297B2
Reaction notes
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