Tetrahydrofuran → methyl 5-amino-4-[7-[(3,5-dichlorophenyl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

HRID 144668

Reaction equation

HRID 144668 reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH3:20][O:21][C:22]([CH2:23][CH2:24][CH:25]([N:26]1[C:27](=[O:36])[c:28]2[cH:29][cH:30][cH:31][c:32]([OH:35])[c:33]2[CH2:34]1)[C:37]([NH2:38])=[O:39])=[O:40].[Cl:55][c:56]1[cH:57][c:58]([CH2:63][OH:64])[cH:59][c:60]([Cl:62])[cH:61]1.[O:41]=[C:42]([O:43][CH:44]([CH3:45])[CH3:46])[N:47]=[N:48][C:49]([O:50][CH:51]([CH3:52])[CH3:53])=[O:54].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[CH3:20][O:21][C:22]([CH2:23][CH2:24][CH:25]([N:26]1[C:27](=[O:36])[c:28]2[cH:29][cH:30][cH:31][c:32]([O:35][CH2:63][c:58]3[cH:57][c:56]([Cl:55])[cH:61][c:60]([Cl:62])[cH:59]3)[c:33]2[CH2:34]1)[C:37]([NH2:38])=[O:39])=[O:40]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 432363,5-Dichlorobenzylic alcoholHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 58389139Methyl 5-amino-4-(4-hydroxy-1-oxoisoindolin-2-yl)-5-oxopentanoate

Product 1

HCID 67335194methyl 5-amino-4-[7-[(3,5-dichlorophenyl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

Sources & evidence

ORD record
ord-66cb09ac7a6a4612a756cde46e3cd9c0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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