Hydrochloric Acid → HCID 178479374, compound
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[ClH:11].[N:12]#[C:13][NH2:14]>C(O)C>[ClH:11].[NH:1]([C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6])[C:13]([NH2:14])=[NH:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3-aminobenzoic acid (Aldrich, 2.74 g, 0.02 mol), hydrochloric acid (12N, 1.66 g, 0.02 mol), and cyanamide (1.64 g, 0.04 mol) in absolute ethanol (50 mL) was heated at reflux for 16 h. The mixture was cooled and the precipitate separated by filtration. The cake was washed several times with ether and dried under vacuum to give 1.05 g (26.6%) of the title compound as an off-white amorphous powder, mp 278° C.
Workup
- temperaturewas heated
- temperatureat reflux for 16 h
- temperatureThe mixture was cooled
- customthe precipitate separated by filtration
- washThe cake was washed several times with ether
- customdried under vacuum
Sources & evidence
- ORD record
- ord-61d0e2cc79214452bc663742e726f5a2
- Source dataset
- uspto-grants-1997_02
- Patent number
- US05602277
Reaction notes
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