Tetrahydrofuran → 4-Chloro-6-((2,6-difluorophenyl)amino)-2-(methylthio)pyrimidine-5-carbaldehyde

HRID 145222

Reaction equation

HRID 145222 reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[Cl:1][c:2]1[n:3][c:4]([S:11][CH3:12])[n:5][c:6]([Cl:10])[c:7]1[CH:8]=[O:9].[F:13][c:14]1[c:15]([NH2:16])[c:17]([F:21])[cH:18][cH:19][cH:20]1>>[c:2]1([NH:16][c:15]2[c:14]([F:13])[cH:20][cH:19][cH:18][c:17]2[F:21])[n:3][c:4]([S:11][CH3:12])[n:5][c:6]([Cl:10])[c:7]1[CH:8]=[O:9]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 796472,6-DifluoroanilineHCID 46140044,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Product 1

HCID 99447374-Chloro-6-((2,6-difluorophenyl)amino)-2-(methylthio)pyrimidine-5-carbaldehyde

Sources & evidence

ORD record
ord-e1840834b1a6400e8adab6cdc23d1e76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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