Hydrochloric Acid → Methyl 12-aminododecanoate--hydrogen chloride (1/1)

HRID 1457531

Reaction equation

HRID 1457531 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[ClH:16].[CH3:17]OC(OC)(C)C>>[ClH:16].[CH3:17][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 6966112-Aminododecanoic Acid

Product 1

HCID 19372000Methyl 12-aminododecanoate--hydrogen chloride (1/1)Yield 90.5%

Procedure

To the suspension of 12-aminododecanoic acid (2.15 g; 10 mmol) in 2,2-dimethoxypropane (100 ml) was added 36% aqueous HCl (10 ml) and the mixture was treated in an ultrasonic bath until all solid material was dissolved. The mixture was then left to stand overnight, concentrated to dryness, dissolved in 40 ml of methanol and precipitated with approximately 500 ml of dry ether to give 2.4 g of 1 (90.5% yield).

Workup

  1. additionthe mixture was treated in an ultrasonic bath until all solid material
  2. dissolutionwas dissolved
  3. waitThe mixture was then left
  4. concentrationconcentrated to dryness
  5. dissolutiondissolved in 40 ml of methanol
  6. customprecipitated with approximately 500 ml of dry ether

Sources & evidence

ORD record
ord-d2eabb1642dc4adaa8ccee71a480e632
Source dataset
uspto-grants-1998_12
Patent number
US05849691

Linked notes

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