L-Hydroxyproline → HCID 54239052, compound
Reaction equation
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].[OH:13][C@H:14]1[CH2:18][NH:17][C@H:16](C(O)=O)[CH2:15]1>CN(C)C=O>[OH:13][CH:14]1[CH2:18][N:17]2[CH:16]([CH2:3][CH:2]3[CH:11]2[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]3)[CH2:15]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
8.6 g (50 mmol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are heated at 120° C. overnight with 6.6 g (50 mmol) of trans-4-hydroxyproline in 200 ml of dimethylformamide. The mixture is concentrated and the residue is distilled.
Workup
- concentrationThe mixture is concentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-d9548029e1d64d3abd8a6a59503991db
- Source dataset
- uspto-grants-1991_12
- Patent number
- US05071999
Reaction notes
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