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Water → 5-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine

HRID 1460956
Notes
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Reaction equation

HRID 1460956 reaction equation
ClC([O:4][C:5]([Cl:8])(Cl)Cl)=O.[Cl:9][C:10]1[C:11]([NH:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][O:29][CH2:30][CH3:31])=[CH:23][C:22]=2[CH3:32])=[N:12][CH:13]=[N:14][C:15]=1[CH3:16].C(N(CC)CC)C.O>C1(C)C=CC=CC=1>[Cl:9][C:10]1[C:11]([N:17]([C:5]([Cl:8])=[O:4])[CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][O:29][CH2:30][CH3:31])=[CH:23][C:22]=2[CH3:32])=[N:12][CH:13]=[N:14][C:15]=1[CH3:16]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 10426Diphosgene2×HCID 139099695-Chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine

Product 1

HCID 150101975-chloro-N-chlorocarbonyl-N-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
5 °C

Procedure

An amount 2.0 g of trichloromethyl chloroformate (TCF) was dissolved in 30 ml of toluene and cooled to 5° C. or lower. To the solution was added dropwise a solution of 5.0 g of 5-chloro-N-{2-[4-(2-ethoxyethyl)2-methylphenoxy]ethyl}-6-methyl-4-pyrimidine amine and 1.8 g of triethylamine dissolved in 20 ml of toluene, and after the dropwise addition, the mixture was stirred at room temperature for 3 hours. After completion of the reaction, 20 ml of water was added, and the mixture was stirred at room temperature for one hour to decompose excessive TCF.

Workup

  1. additionafter the dropwise addition
  2. additionwas added
  3. stirringthe mixture was stirred at room temperature for one hour

Sources & evidence

ORD record
ord-b466e75864cb470e90716710c97d6197
Source dataset
uspto-grants-1991_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05073558

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes