Tetrahydrofuran → 1-Acridinol, 1,2,3,4-tetrahydro-9-amino-6-(trifluoromethyl)-

Reaction equation

[Al+3:22].[H-:21].[H-:24].[H-:25].[H-:26].[Li+:23].[NH2:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([C:17]([F:18])([F:19])[F:20])[cH:7][c:8]2[n:9][c:10]2[c:15]1[C:14](=[O:16])[CH2:13][CH2:12][CH2:11]2.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[NH2:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([C:17]([F:18])([F:19])[F:20])[cH:7][c:8]2[n:9][c:10]2[c:15]1[CH:14]([OH:16])[CH2:13][CH2:12][CH2:11]2

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 13935155HCID 13935155, compound

Product 1

HCID 30256081-Acridinol, 1,2,3,4-tetrahydro-9-amino-6-(trifluoromethyl)-

Sources & evidence

ORD record: ord-da5b36fe8ef14e9aaf12dadefa1d6611
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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