tert-Butyl carbamate → 2-(Tert-butoxycarbonylamino)-6-chloroisonicotinic acid
Reaction equation
CC(C)(C)OC(N)=O.O=C(O)c1cc(Cl)nc(Cl)c1>C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>CC(C)(C)OC(=O)Nc1cc(C(=O)O)cc(Cl)n1Participants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 100 °C
Procedure
Reagents were mixed in a 25 mL round bottom flask and flushed well with nitrogen - heated at 100 °C for 16 h. The mixture looked dark black. Could not detect any starting material or product! It was discarded.
Sources & evidence
- ORD record
- ord-7c9ead47a3324fac997f2b8af6afca02
- Source dataset
- 750 AstraZeneca ELN dataset
- Original link
- View source
Reaction notes
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