Ethyl Acetate → HCID 89389893, compound
Reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:13][CH2:12][C@H:11]([C:14]([OH:17])([CH3:16])[CH3:15])[CH2:10]1)C1C=CC=CC=1.CC(=O)OCC>CCO.[OH-].[OH-].[Pd+2]>[NH2:8][C@H:9]1[CH2:13][CH2:12][C@H:11]([C:14]([OH:17])([CH3:16])[CH3:15])[CH2:10]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 2-(trans-3-(dibenzylamino)cyclopentyl)propan-2-ol (3 g, 9.3 mmol) and Pd(OH)2 (900 mg) in EtOH (30 mL) was hydrogenated under 50 psi of H2 for 48 h at room temperature. TLC (PE:EA=5:1) showed the reaction was complete. The mixture was filtered and concentrated in vacuo to give crude 2-(trans-3-aminocyclopentyl)propan-2-ol (1 g, 77%) as a yellow oil.
Workup
- filtrationThe mixture was filtered
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-f5a31d661d0443e68b6cdd43e9ce8a61
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09416132B2
Reaction notes
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