Water → 4-[(3-Methoxy-5-methyl-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[n:17][cH:18][c:19]([Br:24])[n:20][c:21]2[O:22][CH3:23])[CH2:12][CH2:13]1.[CH3:25][Zn:26][CH3:27].[CH3:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Ni:47]([Cl:48])[Cl:49].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1.[OH2:40].[c:50]1([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[CH2:58][CH2:59][CH2:60][P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[n:17][cH:18][c:19]([CH3:25])[n:20][c:21]2[O:22][CH3:23])[CH2:12][CH2:13]1
