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1,2-Dichloroethane → HCID 117996253, compound

HRID 1488258
Notes
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Reaction equation

HRID 1488258 reaction equation
[CH2:1]([O:8][C:9](=[O:50])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:47](O)=[O:48])[CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:46])[CH2:26][CH2:27][CH2:28][CH2:29][C:30]([NH:32][CH2:33][CH2:34][O:35][C@@H:36]1[O:44][C@@H:43]([CH3:45])[C@@H:41]([OH:42])[C@@H:39]([OH:40])[C@@H:37]1[OH:38])=[O:31])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.[NH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][C:71]([NH:73][CH2:74][CH2:75][O:76][C@@H:77]1[O:85][C@@H:84]([CH3:86])[C@@H:82]([OH:83])[C@@H:80]([OH:81])[C@@H:78]1[OH:79])=[O:72]>CN(C=O)C>[C@@H:77]1([O:76][CH2:75][CH2:74][NH:73][C:71](=[O:72])[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66][NH:65][C:47](=[O:48])[C@@H:19]([NH:18][C:16](=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:50])[CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:46])[CH2:26][CH2:27][CH2:28][CH2:29][C:30](=[O:31])[NH:32][CH2:33][CH2:34][O:35][C@@H:36]2[O:44][C@@H:43]([CH3:45])[C@@H:41]([OH:42])[C@@H:39]([OH:40])[C@@H:37]2[OH:38])[O:85][C@@H:84]([CH3:86])[C@@H:82]([OH:83])[C@@H:80]([OH:81])[C@@H:78]1[OH:79]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 117995908HCID 117995908, compoundHCID 117996333HCID 117996333, compound

Product 1

HCID 117996253HCID 117996253, compound

Reagents, catalysts & solvents 1

HCID 6228
Dimethylformamide
Solvent

Procedure

In a 40 mL vial was added N2-{8-(benzyloxy)-8-oxooctanoyl}-N6-[6-({2-[(α-L-fucopyranosyl)oxy]ethyl}amino)-6-oxohexanoyl]-L-lysine (100 mg, 0.141 mmol) and DMF (5 mL). To the above solution at 0° C. was added EDC (40.5 mg, 0.211 mmol) and HOBt (23.7 mg, 0.155 mmol). The reaction was warmed to rt and stirred at rt for 20 min. To the above mixture was added 6-amino-N-{2-[(α-L-fucopyranosyl)oxy]ethyl}hexanamide (45.1 mg, 0.141 mmol). After stirring at rt for 18 hr, the mixture was concentrated. The residue was purified by flash chromatography eluting with 0-40% AcCN in water to give the title compound. UPLC Method B: m/e=1012.6348 [M+1]; Rt=3.28 min.

Workup

  1. stirringAfter stirring at rt for 18 hr
  2. concentrationthe mixture was concentrated
  3. customThe residue was purified by flash chromatography
  4. washeluting with 0-40% AcCN in water

Sources & evidence

ORD record
ord-4f42af457a41466f8e25a33feda683bd
Source dataset
uspto-grants-2016_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09427475B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes