Benzoic acid, 3,5-difluoro-, ethyl ester → Ethyl 3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

HRID 1490709

Reaction equation

HRID 1490709 reaction equation
CCOC(=O)c1cc(F)cc(F)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC(C)(C)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].O=c1ccc2cccc(-c3ccc(-c4ccccn4)nc3)c2[nH]1.[Ir].[Ir].[K]>CCOC(=O)c1cc(F)c(B2OC(C)(C)C(C)(C)O2)c(F)c1

Participants

7

Reactant 1

HCID 2758826Benzoic acid, 3,5-difluoro-, ethyl ester

Product 1

HCID 90041587Ethyl 3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateYield 93%

Reagents, catalysts & solvents 5

HCID 2733548Bis(pinacolato)diboraneReagentHCID 86639980Potassium tert-butoxideReagentHCID 1646813858-([2,2'-bipyridin]-5-yl)quinolin-2(1H)-oneReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b19398e5bcb248f5a1ef8fcd6b34649a
Source dataset
Borylation dataset from Roche

Linked notes

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