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HCID 178522361, compound → HCID 178431008, compound

HRID 1491459
Notes
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Reaction equation

HRID 1491459 reaction equation
O=C(Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)C1CCC1>CC#N.CC#N.CC#N.CC#N.CC#N.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCC(C)C(NC(C)=O)C1=NC(CC(C)C)CO1.ClCCCl.O=P(O)(O)O.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[K].[Pd+2]>CC1(C)OB(C2CCC2C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)OC1(C)C
ParticipantsConditionsSources & evidenceReaction notes

Participants

8

Reactant 1

HCID 178522361HCID 178522361, compound

Product 1

HCID 178431008HCID 178431008, compoundYield 85%

Reagents, catalysts & solvents 6

HCID 2733548Bis(pinacolato)diboraneReagentHCID 16218557Phosphoric acid (potassium)ReagentHCID 178446396HCID 178446396, compoundReagentHCID 22755518Tetrakis(acetonitrile)palladium(II) Bis(trifluoromethanesulfonate)CatalystHCID 111,2-DichloroethaneSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-d2be20b77be54895af0b984b628dd331
Source dataset
Borylation dataset from Roche
DOI
10.1021/jacs.6b13389

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes