Methanesulfonyl chloride → N-(3-(isoquinolin-3-yl)-4-methylphenyl)-6-(methylsulfonyl)-5,6,7,8-tetrahydro-2,6-naphthyridin-1-amine

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[CH:12]=[C:13]([NH:18][C:19]3[C:28]4[CH2:27][CH2:26][NH:25][CH2:24][C:23]=4[CH:22]=[CH:21][N:20]=3)[CH:14]=[CH:15][C:16]=2[CH3:17])[N:2]=1.CCN(C(C)C)C(C)C.[CH3:38][S:39](Cl)(=[O:41])=[O:40]>C1COCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[CH:12]=[C:13]([NH:18][C:19]3[C:28]4[CH2:27][CH2:26][N:25]([S:39]([CH3:38])(=[O:41])=[O:40])[CH2:24][C:23]=4[CH:22]=[CH:21][N:20]=3)[CH:14]=[CH:15][C:16]=2[CH3:17])[N:2]=1